![]() ![]() These include beta blockers such as propranolol (Inderal, InnoPran XL, others) and metoprolol tartrate (Lopressor). Preventive medication is aimed at reducing how often you get a migraine headache with or without aura, how severe the attacks are, and how long they last. Your doctor might recommend preventive medications if you have frequent, long-lasting or severe headaches that don't respond well to treatment. Medications can help prevent frequent migraines, with or without aura. If you're pregnant or trying to get pregnant, don't use any of these medications without first talking with your doctor. Some of these medications are not safe to take during pregnancy. These are usually taken with pain medications. Anti-nausea drugs include chlorpromazine, metoclopramide (Reglan) or prochlorperazine (Compro). These can help if your migraine with aura is accompanied by nausea and vomiting. Because they can be highly addictive, these are usually used only if no other treatments are effective. For people who can't take other migraine medications, narcotic opioid medications might help. Ubrogepant and rimegepant should not be taken with strong CYP3A4 inhibitor drugs. In drug trials, drugs from this class were more effective than placebo in relieving pain and other migraine symptoms such as nausea and sensitivity to light and sound two hours after taking it.Ĭommon side effects include dry mouth, nausea and excessive sleepiness. Ubrogepant (Ubrelvy) and rimegepant (Nurtec ODT) are oral calcitonin gene-related peptide (CGRP) antagonists recently approved for the treatment of acute migraine with or without aura in adults. Lasmiditan can have a sedative effect and cause dizziness, so people taking it are advised not to drive or operate machinery for at least eight hours.Ĭalcitonin gene-related peptide (CGRP) antagonists. In drug trials, lasmiditan significantly improved headache pain. This newer oral tablet is approved for the treatment of migraine with or without aura. People with coronary artery disease, high blood pressure, or kidney or liver disease should avoid dihydroergotamine. Side effects can include worsening of migraine-related vomiting and nausea. Available as a nasal spray or injection, this drug is most effective when taken shortly after the start of migraine symptoms for migraines that tend to last longer than 24 hours. ![]() They might not be safe for those at risk of a stroke or heart attack.ĭihydroergotamine (D.H.E. Taken as pills, shots or nasal sprays, they can relieve many symptoms of migraine. Prescription drugs such as sumatriptan (Imitrex, Tosymra) and rizatriptan (Maxalt, Maxalt-MLT) are used to treat migraine because they block pain pathways in the brain. Migraine relief medications that combine caffeine, aspirin and acetaminophen (Excedrin Migraine) may be helpful, but usually only against mild migraine pain. ![]() When taken too frequently, these might cause medication-overuse headaches, and possibly ulcers and bleeding in the gastrointestinal tract. These over-the-counter or prescription pain relievers include aspirin or ibuprofen (Advil, Motrin IB, others). Depending on how severe your migraine pain is, types of medications that can be used to treat it include: Medications used to relieve migraine pain work best when taken at the first sign of an oncoming migraine - as soon as signs and symptoms of a migraine aura begin.
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